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Topamax effects on kidneys. I’ve noticed in watching my blog statistics that a previous entry on kidney stones resulting from topiramate (Topamax) use continues to be one of my most visited pages on this blog. So once I found more information about this medication and its effect on kidneys I wanted to make certain to share it.
Within 5 days of starting topiramate, the six subjects during this study experienced a big drop of calcium in their urine of about 31% and citrate by about 40%. When calcium and citrate aren’t exposed within the urine, it’s likely because it’s accumulating elsewhere. Like kidney stones.
Interestingly, increasing the topiramate dose appeared to improve calcium readings and to worsen citrate readings. Meaning you would possibly get less than 1 quiet urinary calculus and more of another.
The authors of this study said that the degree of reduction of urinary citrate was profound enough to be compared to the clinical presentation of renal tubular acidosis. this is often a condition during which the body’s pH is shifted to an unhealthy level, promoting important changes like bone demineralization. And this may cause rickets in children and osteomalacia in adults. These aren’t belongings you will see or feel in those first few days. you would like to live them clinically.
Topamax effects on kidneys
I would strongly recommend if you and your physician have concluded that absolutely the only way to manage your manic depression, your migraine, or your epilepsy, is with topiramate, then you should simply closely monitor your urinary metabolites to make certain you are not doing more harm than good.
And if you’re one among those souls who’s been convinced that it’d be nice to undertake topiramate to ascertain if it helps you lose weight, consider that you simply won’t just be losing fat, you would possibly even be losing bone. what is the point of being thin if you’ve got to vomit once you get there?
The only way to know is to watch. Please don’t stick your head in the sand and hope it isn’t happening to you.